Vagibact Cream (Clindamycin Phosphate Cream USP)

Vagibact Cream Ointment (Clindamycin Phaospahte Cream Gel) Uses, Dosage, Side Effects, Benefits

Vagibact Cream contains the drug named Clindamycin which is a very effective antibiotic. Meanwhile, chemically clindamycin is identified as 7-deoxy, 7-chloro derivative of lincomycin, and antobiotic that elaborate by Streptomyces lincolnesis. It is effective much effective against gram positive organism and anaerobic bacteria.

Vagibact Cream Composition

Each gram cream contains

  • Clidamycin (as PhosphateI UPS) 20 mg

Vagibact Cream Microbiology & Clinical Pharmacology

Clindamycin inhibits bacterial protein systhesis at the level of the bacterial ribosome. Meanwhile, the antibiotic binds preferentially to 50s ribosomal sub unit and affects the process of peptide chain initiation. Although Clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active Clindamycin. In addition, Clindamycin has been shown to be active in vitro against the following organisms which have been associated with

  • Bacterial vaginosis
  • Gardnerella
  • Mobilunous spp
  • Bacteroides spp
  • Mycoplasma Hominis
  • Peptostreptococcus spp

Approximately 4% (range 0.8-8%) of the administered dose of Clindamycin (100 mg in 5g of cream) absorbed after vaginal administration.

Vagibact Cream Ointment Pharmacokinetic Properties

Following a once a day intravaginal dose of 100 mg of Clindamycin phosphate vaginal cream 2%, administered for 7 consecutive days to 5 woman with bacterail vahinosis, absorption was slower and less variable than that observed in healthy females. Approximately 4% (range 2% to 8%) of the dose was absorbed systemically. These peak concentration were attained approximately 14 hours post-dosing (range 4-24 hours). There was little or no systemic accumulation of Clindamycin after repeated (7 day) vaginal dosing of Clindamycin phosphate vaginal cream 2 %. The systemic half-life was 1.5 to 2.6 hours.

Vagibact Cream Gel Indications

Vagibact Cream (Clindamycin Phosphate Vaginal Cream) use for Antibiotic for the treatment of bacterial vaginosis. It can be used in several other conditions as doctors and pharmacist may know better according to the patients conditions.

Vagibact Dosage Administration

  • One patient should use Vagibact Cream (Clindamycin Phosphate Vaginal Gel) Dose of  Approximately 5g of cream intravaginally at bedtime for 7 consecutive nights or as directed by the doctor or the pharmacist.

Vagibact Overdosage

Vaginally applied Clindamycin phosphate vaginal cream 2% can be absorbed in sufficient amounts to produce systemic effects. Meanwhile, In the situation of Vagibact Cream overdosage, general symptomatic and supportive measures are indicated as required. On the other hand, you must contact your doctor or pharmacist immediately.

Vagibact Contraindications

VAGIBACT Cream contra-indicated in patient previously found to be hypersensitive to preparation containing Clindamycin or any of the components of the cream base. Therefore, It should not used in patients having Lincomycin sensitivity, inflamatory bowel disease, or antibiotic associated colitis.

Vagibact Warnings

As there are no data available on the use of VAGIBACT Cream  in patients younger than 12 years of age. So, It should not used in this population.

Vagibact Cream Uses In Pregnancy And Lactation

Reproduction studies have been performed in rats and mice using subcutaneous and oral doses of Clindamycin ranging from 20 to 600 mg/kg/day. And it have revealed no evidence of impaired fertility or harm to the fetus due to Clindamycin. On the other hand, there no adequate and well controlled studies in pregnant woman during their first trimester. However because animal reproduction studies not always predictive of human in pregnant woman during second trimester. Meanwhile, VAGIBACT Cream was effective in treating bacterial vaginosis, and no drug related medical events reported in the neonates. However as with any drug used during pregnancy, a careful risk benefit assessment should considered before using it. Meanwhile, It not known that Clindamycin  excreted in breast milk following the use of vaginally administered Clindamycin phosphate.

Vagibact Cream Side Effects

Like all the other medical products Vagibact Ointment Cream (Clindamycin Vaginal Cream) also shown some side effects. Meanwhile, the following treatment-related adverse events  reported:

  • Cervivitis/vaginitis
  • Vulvo-vaginal irritation
  • Dizziness
  • Headache
  • Vertigo
  • Heartburn
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Abdominal pain
  • Rash
  • Exanthema
  • Urticaria

How To Use and Application of Vagibact Cream (Clindamycin Vaginal Cream)

Plastic applicator provided in pack designed to allow proper vaginal administration of Vagibact. Firstly, Remove cap from cream tube. Secondly,  pierce the seal of the tube by means of the pin on the top of the cap. On the other hand, Screw a plastic applicator on the threaded end of the tube. In addition, Rolling from the bottom, squeeze gently and force the medication into the applicator. At last, The applicator  filled when the plunger reaches its predetermined stopping point.

Vagibact Storage Instructions

Most importantly, Store the cream within 30 C temperature and also avoid to freeze the medicine. On the other hand, avoid to expose the medicine to direct sun light and protect from heat. In conclusion, and the most important thing to say that always keep your medicines out of the reach of your small children because that may be risking their life.

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